Abstract
Oxyphenbutazone was oxidized when incubated with acetone powder prepared from sheep vesicular gland microsomes or with lipoxygenase at pH 4 or 5. Oxidation also occurred at pH 8 or 9, if arachidonate or linoleate was added to either of the incubation mixtures. The oxygenated product was found to be identical with 4-hydroxyoxyphenbutazone, which was synthesized and analyzed by gas liquid chromatography and mass spectrometry. The oxygenated compound was not an inhibitor of prostaglandin biosynthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 748-755 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 7 1975 |
Bibliographical note
Funding Information:A. Pfeiffer Memorial Research Fellowship.
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