TY - JOUR
T1 - Oxidation of low molecular weight chloroalkanes by cytochrome P450CAM
AU - Lefever, Mark R.
AU - Wackett, Lawrence P.
PY - 1994/5/30
Y1 - 1994/5/30
N2 - Cytochrome P450CAM from Pseudomonas putida G786 oxidized chlorinated ethanes and 1,2-dichloropropane. The rate of NADH oxidation decreased with decreasing chlorine substitution. The single detectable oxidation products of 1,1,1-trichloroethane and 1,2-dichloropropane were 1,1,1-trichloroethanol and chloroacetone, respectively. Organic product formation was largely uncoupled from NADH oxidation.
AB - Cytochrome P450CAM from Pseudomonas putida G786 oxidized chlorinated ethanes and 1,2-dichloropropane. The rate of NADH oxidation decreased with decreasing chlorine substitution. The single detectable oxidation products of 1,1,1-trichloroethane and 1,2-dichloropropane were 1,1,1-trichloroethanol and chloroacetone, respectively. Organic product formation was largely uncoupled from NADH oxidation.
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U2 - 10.1006/bbrc.1994.1711
DO - 10.1006/bbrc.1994.1711
M3 - Article
C2 - 8198597
AN - SCOPUS:0028227789
SN - 0006-291X
VL - 201
SP - 373
EP - 378
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -