Oxidation of low molecular weight chloroalkanes by cytochrome P450CAM

Mark R. Lefever, Lawrence P. Wackett

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Cytochrome P450CAM from Pseudomonas putida G786 oxidized chlorinated ethanes and 1,2-dichloropropane. The rate of NADH oxidation decreased with decreasing chlorine substitution. The single detectable oxidation products of 1,1,1-trichloroethane and 1,2-dichloropropane were 1,1,1-trichloroethanol and chloroacetone, respectively. Organic product formation was largely uncoupled from NADH oxidation.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - May 30 1994


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