Oxalosis-induced bone disease: A complication of transplantation and prolonged survival in primary hyperoxaluria. Report of a case

The authors report the case of a child with Type-I primary hyperoxaluria who, at the time of writing, had survived for sixty-one months after a renal transplant and had an unusual bone disorder. She had prolonged hypercalcemia, unaffected by a successful subtotal parathyroidectomy, and progressive, universal, pathological changes in bone, leading to several pathological fractures. A striking clinical feature was the bulbous enlargement of the tips of some of the fingers with extrusion of calcium oxalate from the nail beds. The authors present the findings from radiographic, histological, and electron microscopic studies of the bones of this patient.