Overloaded Hollow‐Fiber Liquid Chromatography

Hongbing Ding, Edward L Cussler Jr

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Liquid chromatography in hollow fibers can separate solutes like flavors and proteins by using a stationary phase of organic solvent, sometimes containing reversed micelles. Such separations, which have a much smaller pressure drop than equivalent separations in packed beds, show dispersion consistent with chromatographic theories at low flows and dilute feeds. These separations behave less predictably at high flows and concentrated feeds, which overload the hollow fibers. The results for flavors correlate well with the Graetz number, consistent with available theories of chromatography and adsorption. The results for proteins correlate poorly with the Graetz number but better with a dimensionless flux based on facilitated diffusion in the stationary phase.

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalBiotechnology Progress
Issue number6
StatePublished - 1990


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