Overexpression of phospholipase A2 group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression

Yan Chun Zhai, Bin Dong, Wen Qiang Wei, Yan He, Xin Qing Li, Robert T. Cormier, Wei Wang, Fen Liu

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2 Scopus citations

Abstract

Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04). Conclusions: Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.

Original languageEnglish (US)
Pages (from-to)9417-9421
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number21
DOIs
StatePublished - 2014

Keywords

  • Cyclooxygenase-2
  • Esophageal SCC
  • Immunohistochemistry
  • Phospholipase A group IIA

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