Overexpression of kinase-dead mTOR impairs glucose homeostasis by regulating insulin secretion and not β-cell mass

Keyphrases

• Mammalian Target of Rapamycin (mTOR) 100%
• Insulin Secretion 100%
• Overexpression 100%
• Glucose Homeostasis 100%
• Cell Mass 100%
• Kinase-dead 100%
• Cell Function 33%
• MTOR Complex 2 (mTORC2) 33%
• Islet 22%
• Glucose Intolerance 22%
• Pdx1 22%
• Cell Growth 11%
• Insulin 11%
• Overexpressing 11%
• Growth Factors 11%
• Signaling Pathway 11%
• Protein Kinase 11%
• Cell Development 11%
• Enzymatic Activity 11%
• High-fat Diet 11%
• Functional Relevance 11%
• Protein Level 11%
• Diabetogenic 11%
• Transcript Level 11%
• Nutrient Factors 11%
• Conserved Protein 11%
• High-fat Diet Mice 11%
• Secretion Defect 11%
• Onodi Cell 11%
• Chow Diet 11%

Biochemistry, Genetics and Molecular Biology

• Insulin Release 100%
• Glucose Homeostasis 100%
• Phosphotransferase 100%
• Kinase 100%
• Mechanistic Target of Rapamycin 100%
• Cell Function 80%
• Transgene 60%
• Mammalian Target of Rapamycin 40%
• Cell Growth 40%
• Enzyme Activity 20%
• Cell Maturation 20%
• Mammalian Target of Rapamycin Complex 1 20%
• Mammalian Target of Rapamycin Complex 2 20%
• Growth Factor 20%
• Protein Kinases 20%
• Protein Kinase A 20%

Immunology and Microbiology

• Sirolimus 100%
• Insulin Release 100%
• Glucose Homeostasis 100%
• Cell Function 80%
• Transgene 60%
• Cell Growth 40%
• Growth Factor 20%
• Cell Maturation 20%
• Enzyme Activity 20%
• Mammalian Target of Rapamycin Complex 1 20%
• Mammalian Target of Rapamycin Complex 2 20%
• Insulin 20%