Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

Woo Young Jang, Ki Beom Bae, Sung Hyun Kim, Dong Hun Yu, Hei Jung Kim, Young Rae Ji, Seo Jin Park, Si Jun Park, Min Cheol Kang, Ja In Jeong, Sang Joon Park, Sang Gyu Lee, Inkyu Lee, Myoung Ok Kim, Duhak Yoon, Zae Young Ryoo

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1's role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume444
Issue number3
DOIs
StatePublished - Feb 14 2014

Bibliographical note

Funding Information:
This research was supported by the Next-Generation BioGreen21 Program (NO. PJ 009573), the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (NO. 2008-0062618).

Keywords

  • Jazf1
  • Lipid accumulation
  • Obesity
  • PEPCK
  • TR4
  • Weight gain

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