Ovarian cancer stem cells and inflammation

Gil Mor, Gang Yin, Ilana Chefetz, Yang Yang, Ayesha Alvero

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Epithelial ovarian cancer (EOC) is the fourth leading cause of cancer-related deaths in women in the United States and the leading cause of gynecologic cancer deaths. The major limiting factor in the treatment of ovarian cancer is recurrence and chemoresistance. Individuals who succumb to advancedstage ovarian cancer inevitably become refractory to chemotherapy, resulting in disease progression and death. The source of recurrence and lack of response to chemotherapy is unknown. The focus of this review is to evaluate the question of recurrence and chemoresistance based on the concept of the cancer stem cells and inflammation.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalCancer Biology and Therapy
Volume11
Issue number8
DOIs
StatePublished - Apr 15 2011

Bibliographical note

Funding Information:
These studies were supported in part by grants from NCI/NIH RO1CA127913, RO1CA118678, The Janet Burros Memorial Foundation, The Sands Family Foundation and the Discovery To Cure Research Program.

Keywords

  • Inflammation
  • Nuclear factor kappab
  • Ovarian cancer
  • Ovarian cancer stem cells
  • Recurrence
  • Toll-like receptors

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