Outsmart HPV: Acceptability and short-term effects of a web-based HPV vaccination intervention for young adult gay and bisexual men

Annie Laurie McRee, Abigail Shoben, Jose A. Bauermeister, Mira L. Katz, Electra D. Paskett, Paul L. Reiter

    Research output: Contribution to journalArticlepeer-review

    34 Scopus citations


    Background: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). Methods: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention). We assessed between group differences in HPV vaccination attitudes and beliefs immediately following the intervention using multiple linear regression. Results: There were no differences in HPV vaccination attitudes, beliefs and intentions between groups at baseline. Compared to participants in the control group, intervention participants reported: greater perception that men who have sex with men are at higher risk for anal cancer relative to other men (b = 0.34); greater HPV vaccination self-efficacy (b = 0.15); and fewer perceived harms of HPV vaccine (b = -0.34) on posttest surveys (all p < .05). Overall, intervention participants reported high levels of acceptability and satisfaction with the Outsmart HPV intervention (all > 4.4 on a 5-point scale). Conclusions: Findings from this study provide preliminary support for a brief, tailored web-based intervention in improving HPV vaccination attitudes and beliefs among YGBM. An important next step is to determine the effects of Outsmart HPV on HPV vaccine uptake. Clinical trials registration: ClinicalTrials.gov identifier NCT02835755.

    Original languageEnglish (US)
    Pages (from-to)8158-8164
    Number of pages7
    Issue number52
    StateAccepted/In press - Jan 1 2018

    Bibliographical note

    Funding Information:
    Supported by the National Cancer Institute of the National Institutes of Health under Award Number R21CA194831. The funder played no role in the design and conduct of the study; collection, management, analysis, and interpretation of data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

    Publisher Copyright:
    © 2018 Elsevier Ltd


    • HPV vaccination
    • Human papillomavirus
    • LGBT
    • Males
    • Young adults

    PubMed: MeSH publication types

    • Journal Article
    • Research Support, N.I.H., Extramural
    • Clinical Trial


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