Outcomes following persistent atrial fibrillation ablation using localized sources identified with Ripple map

Daniel P. Melby, Charles Gornick, Raed Abdelhadi, Jay Sengupta, Manju Pai, John S. Zakaib, Jo Ellyn Moore, David G. Benditt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


BACKGROUND: Ablation of persistent atrial fibrillation (AF) remains challenging. Identification and ablation of localized AF drivers may offer the possibility for improved outcomes. Ripple map is a novel software algorithm that may allow improved localization of possible AF drivers through the whole chamber graphical display of continuously recorded bipolar electrograms. The objective of this study was to determine whether regions of high-frequency Ripple activation (HFRA) observed on Ripple map provide useful ablation targets in patients with persistent AF.

METHODS AND RESULTS: Consecutive patients underwent the first-time ablation of persistent AF (n = 162) using a standard stepwise (n = 105) or a Ripple map guided approach (n = 57). Ripple map guided patients underwent pulmonary vein antral isolation followed by ablation of HFRA sites. Acute termination of AF was observed in 91.2% of the Ripple-guided patients vs 52.4% in the stepwise approach, P < .0001. Following a single ablation procedure, after 18 months 98.2% of Ripple map guided patients were free of AF, compared with 81.4% of standard stepwise ablation (P = .005). Freedom from atrial tachycardia (54.4% Ripple map vs 52.4% standard, P = .9) or any atrial arrhythmia (52.6% Ripple map vs 39.0% standard, P = .10) did not differ between the two strategies. In a subset analysis (n = 30 of 56), Ripple map regions corresponded to sites with spatiotemporal dispersion in all atrial locations. No differences were observed in the rate of procedural complications.

CONCLUSIONS: Ablation of HFRA sites identified with Ripple map resulted in a higher rate of acute termination and improved freedom from AF compared to a standard stepwise approach.

Original languageEnglish (US)
Pages (from-to)1860-1867
Number of pages8
JournalJournal of cardiovascular electrophysiology
Issue number10
StatePublished - Oct 1 2019

Bibliographical note

Funding Information:
The authors wish to thank Ross Garberich for his statistical expertise, and Dr. Kanagaratnam, Imperial College Healthcare NHS, for his development of the Ripple map algorithm. DGB is supported in part by a grant from the Dr Earl E. Bakken family in support of Heart-Brain research.

Publisher Copyright:
© 2019 The Authors. Journal of Cardiovascular Electrophysiology Published by Wiley Periodicals, Inc.


  • Ripple map
  • atrial fibrillation
  • catheter ablation
  • outcomes

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Outcomes following persistent atrial fibrillation ablation using localized sources identified with Ripple map'. Together they form a unique fingerprint.

Cite this