Outcomes following more than two decades of paediatric cardiac transplantation

Claire A. Irving, Richard Kirk, Gareth Parry, Leslie Hamilton, John H. Dark, Neil Wrightson, Massimo Griselli, Asif Hasan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective: There have been significant changes in the field of paediatric cardiac transplantation over the last two decades. We report experience of over 22 years from a single UK transplant centre. Methods: A total of 189 orthotopic cardiac transplants were performed in 182 children aged <18 years between March 1987 and March 2009 in our institution. Patients were identified and outcomes reviewed using the cardiopulmonary transplant database and hospital medical records. Results: 182 patients underwent cardiac transplantation, mean age 8.3 years (0.1-17.9 years), 91 (50%) male. Mean follow-up time was 9.0 years (0.3-22.3 years). 117 patients (64%) had a diagnosis of cardiomyopathy, 65 (36%) had congenital heart disease. There was no significant difference in age at transplant between the group with cardiomyopathy and the group with congenital heart disease. 32 patients (17.6%) were on mechanical support prior to transplant. Three (1.6%) patients have required long-term renal replacement therapy post transplant, and 16 (8.8%) developed post-transplant lymphoproliferative disease. Survival was 93% at 30 days, 89% at 1 year, 85% at 5 years, 70% at 10 years and 67% at 15 years with a decrease in mortality over time. Seven patients (3.8%) were re-transplanted. Conclusions: Outcomes following cardiac transplantation in childhood are improving with increased experience. There has been a reduction in 30-day mortality over time.

Original languageEnglish (US)
Pages (from-to)1197-1202
Number of pages6
JournalEuropean Journal of Cardio-thoracic Surgery
Volume40
Issue number5
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

Keywords

  • Heart
  • Outcomes
  • Paediatric
  • Transplantation

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    Irving, C. A., Kirk, R., Parry, G., Hamilton, L., Dark, J. H., Wrightson, N., Griselli, M., & Hasan, A. (2011). Outcomes following more than two decades of paediatric cardiac transplantation. European Journal of Cardio-thoracic Surgery, 40(5), 1197-1202. https://doi.org/10.1016/j.ejcts.2011.02.054