Outcomes after simultaneous kidney-pancreas versus pancreas after kidney transplantation in the current era

Sandesh Parajuli, Annamalai Arunachalam, Kurtis J. Swanson, Fahad Aziz, Neetika Garg, Robert R. Redfield, Dixon Kaufman, Arjang Djamali, Jon Odorico, Didier A. Mandelbrot

Research output: Contribution to journalArticlepeer-review

Abstract

Simultaneous pancreas and kidney (SPK) and pancreas after kidney (PAK) transplant are both potential options for diabetic ESRD patients. Historically, PAK pancreas graft outcomes were felt to be inferior to SPK pancreas graft outcomes. Little is known about outcomes in the modern era of transplantation. We analyzed our SPK and PAK recipients transplanted between 01/2000 and 12/2016. There were a total of 635 pancreas and kidney transplant recipients during the study period, 611 SPK and 24 PAK. Twelve of the PAK patients received a living donor kidney. There were no significant differences between the two groups in kidney or pancreas graft rejection at 1 year. Similarly, 1-year graft survival for both organs was not different. At last follow-up, uncensored and death-censored graft survival was not statistically different for kidney or pancreas grafts. In addition, in Cox regression analysis SPK and PAK were associated with similar graft survival. Although the majority of pancreas transplants are in the form of SPK, PAK is an acceptable alternative. Simultaneous pancreas and kidney avoids donor risks associated with live donation, so may be preferable in regions with short wait times, but PAK with a living donor kidney may be the best alternative in regions with long SPK wait times.

Original languageEnglish (US)
Article numbere13732
JournalClinical Transplantation
Volume33
Issue number12
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Bibliographical note

Funding Information:
Funding information This work was supported by an unrestricted research grant from the Virginia Lee Cook Foundation. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

  • kidney outcomes
  • PAK pancreas outcomes
  • simultaneous pancreas and kidney

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