Otosclerosis: etiopathogenesis and histopathology

Sebahattin Cureoglu, Patricia A. Schachern, Alfio Ferlito, Alessandra Rinaldo, Vladimir Tsuprun, Michael M. Paparella

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Otosclerosis is a disease of the bony labyrinth manifesting clinically as a progressive conductive hearing loss, a mixed-type hearing loss, or a sensorineural hearing loss. The age of onset of the hearing loss caused by otosclerosis is principally between 15 and 40 years. Although histopathological inner ear changes due to otosclerosis have been very well documented, the true etiopathogenesis of the disease has yet to be described despite intensive research. Both genetic and environmental factors have been implicated, however.

Original languageEnglish (US)
Pages (from-to)334-340
Number of pages7
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number5
StatePublished - Sep 2006

Bibliographical note

Funding Information:
This study was supported by Hubbard Broadcasting Foundation, Saint Paul, MN and The Starkey Hearing Foundation Eden Prairie, MN.

Copyright 2008 Elsevier B.V., All rights reserved.


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