Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation

T. Jensen, J. Baas, A. Dolathshahi-Pirouz, T. Jacobsen, G. Singh, J. V. Nygaard, M. Foss, J. Bechtold, C. Bünger, F. Besenbacher, K. Søballe

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37 Scopus citations

Abstract

We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume99 A
Issue number1
DOIs
StatePublished - Oct 2011

Keywords

  • biocompatibility
  • composite
  • hydroxyapatite
  • osteointegration
  • osteopontin

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