Osteoblasts: Function, development, and regulation

Elizabeth W. Bradley, Jennifer J. Westendorf, Andre J. Van Wijnen, Amel Dudakovic

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Osteoblasts are derived from a variety of progenitor populations, including bone marrow, neural crest, and periosteal cells. Osteoblasts produce extracellular matrix proteins and paracrine factors that together support formation of bone tissue. The major function of osteoblasts is to produce the organic constituents of the bone extracellular matrix that facilitate its mineralization by inorganic compounds. Mesenchymal stromal/stem cells (MSCs) are considered the developmental precursors of osteoblasts. Transcriptional regulation of gene expression in osteoblasts is controlled by epigenetic events that are important for normal osteoblast differentiation and function. The commitment of MSCs into the osteoblast lineage is controlled by molecular mechanisms including signaling pathways, transcription factors, and epigenetic mechanisms. Epigenetic events coordinated by histone or DNA-modifying proteins and noncoding RNAs amplify and promote retention of tissue specific functions. Understanding these events is essential for understanding bone degeneration and regeneration, and permits design of strategies that may prevent or mitigate bone-related disorders.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
PublisherWiley
Pages31-37
Number of pages7
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
StatePublished - Jan 1 2018

Keywords

  • Developmental precursors
  • Epigenetic events
  • Mesenchymal stromal/stem cells
  • Molecular mechanisms
  • Osteoblasts
  • Transcriptional regulation

Fingerprint Dive into the research topics of 'Osteoblasts: Function, development, and regulation'. Together they form a unique fingerprint.

Cite this