Osmolality Changes in Perilymph After Systemic Administration of Glycerin

S. K. Juhn, S. Prado, J. Pearce

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Blood osmolality was altered in guinea pigs by intravenous administration of glycerin (glycerol). After glycerin administration, serum osmolality increased rapidly, reaching a plateau within 15 minutes. Perilymph osmolality lagged significantly behind the increase of serum osmolality and equalled serum osmolality only after one hour. While perilymph osmolality responded to changes of serum osmolality, there was some time lag noted in the response of perilymph, suggesting the existence of a blood-labyrinth barrier. It was observed that this barrier is permeable to glycerin and water, suggesting the possibility of transient reduction of hydrostatic pressure in the labyrinth by the injection of an osmotic agent into the systemic circulation.

Original languageEnglish (US)
Pages (from-to)683-685
Number of pages3
JournalArchives of Otolaryngology
Issue number11
StatePublished - 1976


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