Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cells

Chun C. Chao, Genya Gekker, Wen Sheng, Shuxian Hu, Horace H Loh, Phillip K. Peterson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We found that orphan opioid receptor (OR) mRNA was constitutively expressed in human fetal microglia, astrocytes, and cerebral cortical neurons. An OR antisense oligonucleotide markedly inhibited HIV-1 expression in enriched microglial cell and the mixed glial/neuronal cell cultures but not in the chronically infected promonocytic U1 cells. The sense oligonucleotide also inhibited HIV-1 expression in brain cell cultures. These findings indicate that while human brain cells constitutively express mRNA for OR, antisense oligonucleotides to OR non-specifically inhibit acute HIV- 1 infection.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalAdvances in experimental medicine and biology
Volume437
DOIs
StatePublished - Jan 1 1998

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