Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides

Myung Ryul Lee, Tami L. Raguse, Marina Schinnerl, William C. Pomerantz, Xiaodong Wang, Peter Wipf, Samuel H. Gellman

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

β-Peptides containing residues derived from trans-2- aminocyclohexanecarboxylic acid (ACHC) display high population of 14-helical secondary structure in aqueous solution. We show that hydrophobic interactions between cyclohexyl rings are not responsible for this conformationpromoting effect, and that polar groups may be attached to the cyclohexyl ring without diminishing the effect.

Original languageEnglish (US)
Pages (from-to)1801-1804
Number of pages4
JournalOrganic Letters
Volume9
Issue number9
DOIs
StatePublished - Apr 26 2007

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