Origins of CD4+ effector and central memory T cells

Marion Pepper, Marc K. Jenkins

Research output: Contribution to journalReview articlepeer-review

299 Scopus citations


Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH 1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH 2 cell, TH 17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.

Original languageEnglish (US)
Pages (from-to)467-471
Number of pages5
JournalNature immunology
Issue number6
StatePublished - Jun 2011


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