Origin of Chronic Myelocytic Leukemia in a Precursor of Pre-B Lymphocytes

Tucker W LeBien, John Hozier, Jun Minowada, John H. Kersey

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

THE cause of the malignant transformation of hematopoietic cells in human chronic myelocytic leukemia is unknown. However, the demonstration of a characteristic and specific chromosomal rearrangement involving chromosomes 9 and 22,1 , 2 known as the Philadelphia chromosome, has suggested a common causative factor in this disorder. In addition, studies of the Philadelphia chromosome and the X-linked enzyme glucose-6-phosphate dehydrogenase have implied that the origin of chronic myelocytic leukemia is a monoclonal stem cell.3 , 4 The studies strongly suggested that, in at least some of these patients, the cellular target of malignant transformation is a progenitor with the potential for differentiation into granulocytes,.

Original languageEnglish (US)
Pages (from-to)144-147
Number of pages4
JournalNew England Journal of Medicine
Volume301
Issue number3
DOIs
StatePublished - Jul 19 1979

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