Origin in tobacco smoke of n′-nitrosonornicotine, a tobacco-specific carcinogen: Brief communication

Dietrich Hoffmann, Michael Dong, Stephen S. Hecht

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


To evaluate risk factors and to approach methods of reduction of the carcinogenic potential of cigarette smoke, the transfer rate of N-nitrosonornicotine in a popular U.S. blended cigarette into mainstream smoke was quantitatively determined. The mean transfer rate was 11.3%; thus ≈46% of the tobacco-specific carcinogen In the smoke came from the tobacco, and the remainder was synthesized during smoking.

Original languageEnglish (US)
Pages (from-to)1841-1844
Number of pages4
JournalJournal of the National Cancer Institute
Issue number6
StatePublished - Jun 1977

Bibliographical note

Funding Information:
ABBREVIATIONS USED: NNN = N'-nitrosonornicotine; GLC = gas liquid chromatography; HPLC = high-pressure liquid chromatography. 1 Received August 4, 1976; accepted November 29, 1976. 2 Supported by Public Health Service contract NOI-CP55666 from the Division of Cancer Cause and Prevention, National Cancer Institute (NCI). 3 No. LII of "Chemical Studies on Tobacco Smoke." 4 Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, N.Y. 10595. 5 Recipient of Public Health Service Career Development Award 1- K04-CAOOI24 from the NCI. 6 We thank W. Z. Maddox and M. R. Guerin, Analytical Chemistry Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, for supplying an "Automatic Syringe Applicator for Cigarettes."


Dive into the research topics of 'Origin in tobacco smoke of n′-nitrosonornicotine, a tobacco-specific carcinogen: Brief communication'. Together they form a unique fingerprint.

Cite this