Origin and evolution of pathogenic coronaviruses

Jie Cui, Fang Li, Zheng Li Shi

Research output: Contribution to journalReview articlepeer-review

3553 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalNature Reviews Microbiology
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2019

Bibliographical note

Publisher Copyright:
© 2018, Springer Nature Limited.

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