Orientation selective deep brain stimulation

Lauri J Lehto, Julia P. Slopsema, Matthew D Johnson, Artem Shatillo, Benjamin A. Teplitzky, Lynn Utecht, Gregor Adriany, Silvia Mangia, Alejandra Sierra, Walter C Low, Olli Gröhn, Shalom Michaeli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective. Target selectivity of deep brain stimulation (DBS) therapy is critical, as the precise locus and pattern of the stimulation dictates the degree to which desired treatment responses are achieved and adverse side effects are avoided. There is a clear clinical need to improve DBS technology beyond currently available stimulation steering and shaping approaches. We introduce orientation selective neural stimulation as a concept to increase the specificity of target selection in DBS. Approach. This concept, which involves orienting the electric field along an axonal pathway, was tested in the corpus callosum of the rat brain by freely controlling the direction of the electric field on a plane using a three-electrode bundle, and monitoring the response of the neurons using functional magnetic resonance imaging (fMRI). Computational models were developed to further analyze axonal excitability for varied electric field orientation. Main results. Our results demonstrated that the strongest fMRI response was observed when the electric field was oriented parallel to the axons, while almost no response was detected with the perpendicular orientation of the electric field relative to the primary fiber tract. These results were confirmed by computational models of the experimental paradigm quantifying the activation of radially distributed axons while varying the primary direction of the electric field. Significance. The described strategies identify a new course for selective neuromodulation paradigms in DBS based on axonal fiber orientation.

Original languageEnglish (US)
Article number016016
JournalJournal of neural engineering
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2017

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Deep Brain Stimulation
Brain
Electric fields
Axons
Magnetic Resonance Imaging
Corpus Callosum
Electrodes
Theoretical Models
Fiber reinforced materials
Technology
Neurons
Rats
Therapeutics
Chemical activation
Fibers
Monitoring
Direction compound

Keywords

  • deep brain stimulation
  • fMRI
  • orientation selective stimulation
  • rat

Cite this

Lehto, L. J., Slopsema, J. P., Johnson, M. D., Shatillo, A., Teplitzky, B. A., Utecht, L., ... Michaeli, S. (2017). Orientation selective deep brain stimulation. Journal of neural engineering, 14(1), [016016]. https://doi.org/10.1088/1741-2552/aa5238

Orientation selective deep brain stimulation. / Lehto, Lauri J; Slopsema, Julia P.; Johnson, Matthew D; Shatillo, Artem; Teplitzky, Benjamin A.; Utecht, Lynn; Adriany, Gregor; Mangia, Silvia; Sierra, Alejandra; Low, Walter C; Gröhn, Olli; Michaeli, Shalom.

In: Journal of neural engineering, Vol. 14, No. 1, 016016, 01.02.2017.

Research output: Contribution to journalArticle

Lehto, LJ, Slopsema, JP, Johnson, MD, Shatillo, A, Teplitzky, BA, Utecht, L, Adriany, G, Mangia, S, Sierra, A, Low, WC, Gröhn, O & Michaeli, S 2017, 'Orientation selective deep brain stimulation', Journal of neural engineering, vol. 14, no. 1, 016016. https://doi.org/10.1088/1741-2552/aa5238
Lehto LJ, Slopsema JP, Johnson MD, Shatillo A, Teplitzky BA, Utecht L et al. Orientation selective deep brain stimulation. Journal of neural engineering. 2017 Feb 1;14(1). 016016. https://doi.org/10.1088/1741-2552/aa5238
Lehto, Lauri J ; Slopsema, Julia P. ; Johnson, Matthew D ; Shatillo, Artem ; Teplitzky, Benjamin A. ; Utecht, Lynn ; Adriany, Gregor ; Mangia, Silvia ; Sierra, Alejandra ; Low, Walter C ; Gröhn, Olli ; Michaeli, Shalom. / Orientation selective deep brain stimulation. In: Journal of neural engineering. 2017 ; Vol. 14, No. 1.
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