Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition

Lin Wu, Antonietta Canna, Omar Narvaez, Jun Ma, Sheng Sang, Lauri J. Lehto, Alejandra Sierra, Heikki Tanila, Yuan Zhang, Olli Gröhn, Walter C. Low, Pavel Filip, Silvia Mangia, Shalom Michaeli

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The recently introduced orientation selective deep brain stimulation (OS-DBS) technique freely controls the direction of the electric field’s spatial gradient by using multiple contacts with independent current sources within a multielectrode array. The goal of OS-DBS is to align the electrical field along the axonal track of interest passing through the stimulation site. Here we utilized OS-DBS with a planar 3-channel electrode for stimulating the rat entorhinal cortex (EC) and medial septal nucleus (MSN), two promising areas for DBS treatment of Alzheimer’s disease. The brain responses to OS-DBS were monitored by whole brain functional magnetic resonance imaging (fMRI) at 9.4 T with Multi-Band Sweep Imaging with Fourier Transformation (MB-SWIFT). Varying the in-plane OS-DBS stimulation angle in the EC resulted in activity modulation of multiple downstream brain areas involved in memory and cognition. Contrary to that, no angle dependence of brain activations was observed when stimulating the MSN, consistent with predictions based on the electrode configuration and on the main axonal directions of the targets derived from diffusion MRI tractography and histology. We conclude that tuning the OS-DBS stimulation angle modulates the activation of brain areas relevant to Alzheimer’s disease, thus holding great promise in the DBS treatment of the disease.

Original languageEnglish (US)
Article number8565
JournalScientific reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health U01 NS103569, the Center for Magnetic Resonance Research NIH core grant P41 EB027061, the EU H2020 Marie Skłodowska RISE project #691110 (MICROBRADAM), Erkko foundation (OG) and Academy of Finland Academy of Finland #323385 and Jane and Aatos Erkko Foundation (AS). The authors are grateful to Dr. Fabrizio Esposito for helpful discussions.

Publisher Copyright:
© 2022, The Author(s).

Center for Magnetic Resonance Research (CMRR) tags

  • NFMC
  • NM
  • P41

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition'. Together they form a unique fingerprint.

Cite this