Orientation and function of the nuclear-centrosomal axis during cell migration

G. W Gant Luxton, Gregg G. Gundersen

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

A hallmark of polarity in most migrating cells is the orientation of the nuclear centrosomal (NC) axis relative to the front-back cellular axis. Here, we review 'effector functions' associated with the NC axis during cell migration. We highlight recent research that has demonstrated that the orientation of the NC axis depends upon the coordinated, but separate positioning of the nucleus and the centrosome. We stress the importance of environmental factors such as cell-cell contacts and substrate topology for NC axis orientation. Finally, we summarize tests of the significance of this axis for cell migration and disease.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume23
Issue number5
DOIs
StatePublished - Oct 2011

Bibliographical note

Funding Information:
This work is supported by National Institutes of Health grants to G.G.G. and a Dystonia Medical Research Foundation fellowship to G.W.G.L. The authors apologize for not being able to discuss all relevant and important data in this review owing to space limitations.

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