Organophosphate exposure inhibits non‐specific esterase staining in human blood monocytes

Jack S. Mandel, Norman T. Berlinger, Neil Kay, John Connett, Martin Reape

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The objective of this study was to investigate the association between exposure to triaryl phosphate and monocyte nonspecific esterase staining activity in workers from a plant in Nitro, West Virginia. A cross‐sectional study design was used to identify the exposed plant employees, and both a plant and a general population group. In addition to completing a questionnaire for each participant, 30 cc of blood were drawn and analyzed using four techniques, two morphological and two enzymatic. These procedures included a Technicon D‐90 autoanalyzer, a Technicon H‐6000 autoanalyzer, a manual enzymatic using alpha naphthyl butyrate, and a manual morphologic using Wright‐Giesma stain. The results showed a decrease in nonspecific esterase staining with the Technicon D‐90. No significant effect on monocyte numbers or esterase positivity was found with the other three techniques.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalAmerican Journal of Industrial Medicine
Volume15
Issue number2
DOIs
StatePublished - 1989

Keywords

  • Technicon D‐90
  • monocyte inhibition
  • organophosphate
  • screening questionnaire

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