Abstract
Tissues from weanling and 19-month-old Sprague Dawley rats were spectrophotofluorometrically analyzed for organic solvent soluble lipofuscin pigments (OLP) and assayed for glutathione peroxidase (GSH-Px) activity. Significantly lower levels of OLP and higher levels of GSH-Px activity were found in the kidney, heart and testis at 19 months of age than were found in weanling rats. No age-related differences in OLP were observed in the brain, lung or liver. The results appeared to indicate an inverse relationship between OLP and GSH-Px activity in some tissues, but the magnitude of the changes observed coupled with conflicting observations in the liver suggested that GSH-Px activity and OLP concentrations were not directly related.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-147 |
| Number of pages | 5 |
| Journal | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition |
| Volume | 56 |
| Issue number | 2 |
| State | Published - Jan 1 1986 |