Organ Transplantation for Cystic Fibrosis

Matthew R. Morrell, Sarah C. Kiel, Joseph M. Pilewski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cystic fibrosis (CF) remains the most common indication for lung transplantation in children and the third most common in adults and has the highest median survival posttransplant for all pretransplant diagnoses. Criteria for transplant in patients with CF vary widely among transplant centers and early referral to multiple centers may be needed to maximize opportunities for lung transplantation. Comorbidities unique to CF such as resistant and atypical pathogens like Burkholderia and Mycobacterium abscessus, and cirrhosis require special consideration for lung transplantation but should not be considered as absolute contraindications. For those patients who are listed for lung transplantation, mechanical support with extracorporeal membrane oxygenation and mechanical ventilation can be efficacious as bridges to lung transplantation in experienced centers with adequate resources. Liver and pancreas transplantations are also acceptable options for end-organ disease related to CF and can provide improvements in both quantity and quality of life.

Original languageEnglish (US)
Pages (from-to)842-856
Number of pages15
JournalSeminars in Respiratory and Critical Care Medicine
Volume40
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Burkholderia
  • cystic fibrosis
  • extracorporeal membrane oxygenation
  • lung transplantation
  • multiorgan transplantation
  • nontuberculous mycobacteria

PubMed: MeSH publication types

  • Journal Article
  • Review

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