Oral ofloxacin versus cefaclor for LRTIs in adults

D. S. Dark, M. Farber, Kathryn L Rice, D. Levin, W. Merrill, M. Mufson, D. Pitrak, B. Varkey

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Ofloxacin (400 mg q12h) and cefaclor (250 to 500 mg q8h) were compared during a 7- to 14-day course of treatment in 98 patients with lower respiratory tract infections (LRTIs). Clinical cure or improvement occurred in 87.8% of patients in the ofloxacin group versus 81.6% in the cefaclor group. In the ofloxacin group, there was bacteriologic eradication of 85% of pathogens, compared with 48% of pathogens in the cefaclor group. Adverse events were reported hy a comparable proportion of patients in each treatment group.

Original languageEnglish (US)
Pages (from-to)551-556
Number of pages6
JournalInfections in Medicine
Issue number10
StatePublished - 1995
Externally publishedYes


  • bronchitis
  • cefaclor
  • infection, respiratory tract
  • ofloxacin
  • pneumonia


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