Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine

Wim Derave, Els Vanden Eede, Peter Hespel, Steven G Carmella, Stephen S Hecht

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. Methods: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. Results and conclusion: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.

Original languageEnglish (US)
Pages (from-to)332-333
Number of pages2
JournalNutrition
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Cancer
  • Nitrite
  • Nutritional supplement

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