Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Prokopios Argyris, Robyn C Reed, J. Carlos Manivel, Dolores Lopez-Terrada, Jared Jakacky, Zuzan Cayci, Konstantinos I. Tosios, Stefan E. Pambuccian, Lester D.R. Thompson, Ioannis G Koutlas

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we present the clinical, radiographic, histopathologic, immunohistochemical and molecular features of two examples of ASPS affecting the oral cavity of 4 and 13 year-old boys, along with a focused review of the literature on intraoral ASPS in pediatric patients.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalHead and Neck Pathology
Volume7
Issue number1
DOIs
StatePublished - Mar 2013

Bibliographical note

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • ASPSCR1/TFE3 fusion
  • Alveolar soft sarcoma
  • Children
  • Immunohistochemistry
  • Management
  • Molecular
  • Oral cavity
  • Pathology
  • Tongue

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