Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Prokopios Argyris; Robyn C Reed; J. Carlos Manivel; Dolores Lopez-Terrada; Jared Jakacky; Zuzan Cayci; Konstantinos I. Tosios; Stefan E. Pambuccian; Lester D.R. Thompson; Ioannis G Koutlas

doi:10.1007/s12105-012-0395-y

Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Prokopios Argyris, Robyn C Reed, J. Carlos Manivel, Dolores Lopez-Terrada, Jared Jakacky, Zuzan Cayci, Konstantinos I. Tosios, Stefan E. Pambuccian, Lester D.R. Thompson, Ioannis G Koutlas

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Abstract

Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we present the clinical, radiographic, histopathologic, immunohistochemical and molecular features of two examples of ASPS affecting the oral cavity of 4 and 13 year-old boys, along with a focused review of the literature on intraoral ASPS in pediatric patients.

Original language	English (US)
Pages (from-to)	40-49
Number of pages	10
Journal	Head and Neck Pathology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/s12105-012-0395-y
State	Published - Mar 2013

Keywords

ASPSCR1/TFE3 fusion
Alveolar soft sarcoma
Children
Immunohistochemistry
Management
Molecular
Oral cavity
Pathology
Tongue

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title = "Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature",

abstract = "Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we present the clinical, radiographic, histopathologic, immunohistochemical and molecular features of two examples of ASPS affecting the oral cavity of 4 and 13 year-old boys, along with a focused review of the literature on intraoral ASPS in pediatric patients.",

keywords = "ASPSCR1/TFE3 fusion, Alveolar soft sarcoma, Children, Immunohistochemistry, Management, Molecular, Oral cavity, Pathology, Tongue",

author = "Prokopios Argyris and Reed, {Robyn C} and Manivel, {J. Carlos} and Dolores Lopez-Terrada and Jared Jakacky and Zuzan Cayci and Tosios, {Konstantinos I.} and Pambuccian, {Stefan E.} and Thompson, {Lester D.R.} and Koutlas, {Ioannis G}",

year = "2013",

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doi = "10.1007/s12105-012-0395-y",

language = "English (US)",

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journal = "Head and Neck Pathology",

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publisher = "Humana Press",

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T2 - Report of Two Cases and Review of Literature

AU - Argyris, Prokopios

AU - Reed, Robyn C

AU - Manivel, J. Carlos

AU - Lopez-Terrada, Dolores

AU - Jakacky, Jared

AU - Cayci, Zuzan

AU - Tosios, Konstantinos I.

AU - Pambuccian, Stefan E.

AU - Thompson, Lester D.R.

AU - Koutlas, Ioannis G

PY - 2013/3

Y1 - 2013/3

N2 - Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we present the clinical, radiographic, histopathologic, immunohistochemical and molecular features of two examples of ASPS affecting the oral cavity of 4 and 13 year-old boys, along with a focused review of the literature on intraoral ASPS in pediatric patients.

AB - Alveolar soft part sarcoma (ASPS) constitutes a rare soft tissue malignant neoplasm comprising less than 1 % of all soft tissue sarcomas. ASPS demonstrates a strong predilection for adolescents and young adults, with a female predominance reported. The head and neck region is the most commonly affected region in pediatric patients with the tongue and orbit affected most commonly. Herein we present the clinical, radiographic, histopathologic, immunohistochemical and molecular features of two examples of ASPS affecting the oral cavity of 4 and 13 year-old boys, along with a focused review of the literature on intraoral ASPS in pediatric patients.

KW - ASPSCR1/TFE3 fusion

KW - Alveolar soft sarcoma

KW - Children

KW - Immunohistochemistry

KW - Management

KW - Molecular

KW - Oral cavity

KW - Pathology

KW - Tongue

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IS - 1

ER -

Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Abstract

Keywords

UN SDGs

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