OPTN/SRTR 2018 Annual Data Report: Hepatitis C

J. H. Wang, S. K. Gustafson, M. A. Skeans, J. R. Lake, W. R. Kim, B. L. Kasiske, A. K. Israni, A. Hart

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Abstract

Direct acting antivirals (DAAs) have fundamentally changed the treatment of hepatitis C virus (HCV) infection and reduced the discard rate of HCV-infected organs by offering a treatment option with a high likelihood of cure posttransplant. This has spurred increased interest in transplanting organs from HCV-positive donors into recipients both with and without HCV. In this chapter, we examine data from 2007 to 2018 to determine trends in HCV (+) donor transplants across various organ types. Since 2015, willingness to accept HCV (+) organs increased for candidates waitlisted for kidney, lung, heart, and pancreas transplant, but decreased for those listed for intestine transplant. For candidates listed for liver transplant, willingness to accept HCV (+) organs decreased from 2007 to 2017, but began increasing in 2017. Willingness to accept was not concentrated in a single US geographic area, and there was substantial variation among transplant programs and donation service areas. Numbers of anti-HCV (+) donor kidney, heart, lung, and liver transplants have increased considerably in the past few years. Short-term allograft survival for kidney and liver transplant recipients of anti-HCV (+) organs appears to be comparable to that for recipients of anti-HCV (-) organs in an unadjusted analysis. However, an unadjusted analysis indicates that long-term allograft survival may be worse. Kidney transplant between HCV-infected donors and uninfected recipients with posttransplant DAA treatment is an emerging area. Short-term data are promising, with similar 1-year allograft survival compared with HCV-uninfected donor to HCV-uninfected recipient kidney transplants in unadjusted analyses. However, long-term data are lacking and close monitoring in the future is warranted.

Original languageEnglish (US)
Pages (from-to)542-568
Number of pages27
JournalAmerican Journal of Transplantation
Volume20
Issue numbers1
DOIs
StatePublished - Jan 1 2020

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Wang, J. H., Gustafson, S. K., Skeans, M. A., Lake, J. R., Kim, W. R., Kasiske, B. L., Israni, A. K., & Hart, A. (2020). OPTN/SRTR 2018 Annual Data Report: Hepatitis C. American Journal of Transplantation, 20(s1), 542-568. https://doi.org/10.1111/ajt.15679