Optimizing the program-specific reporting of pancreas transplant outcomes

B. L. Kasiske, S. Gustafson, N. Salkowski, P. G. Stock, D. A. Axelrod, R. Kandaswamy, E. F. Sleeman, J. Wainright, A. K. Israni, J. J. Snyder

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The Scientific Registry of Transplant Recipients is charged with providing program-specific reports for organ transplant programs in the United States. Monitoring graft survival for pancreas transplant programs has been problematic as there are three different pancreas transplant procedures that may have different outcomes, and analyzing them separately reduces events and statistical power. We combined two consecutive 2.5-year cohorts of transplant recipients to develop Cox proportional hazards models predicting outcomes, and tested these models in the second 2.5-year cohort. We used separate models for 1- and 3-year graft and patient survival for each transplant type: simultaneous pancreas-kidney (SPK), pancreas after kidney (PAK) and pancreas transplant alone (PTA). We first built a predictive model for each pancreas transplant type, and then pooled the transplant types within centers to compare total observed events with total predicted events. Models for 1-year pancreas graft and patient survival yielded C statistics of 0.65 (95% confidence interval, 0.63-0.68) and 0.66 (0.61-0.72), respectively, comparable to C statistics for 1-year patient and graft survival for other organ transplants. Model calibration (Hosmer-Lemeshow method) was also acceptable. We conclude that pooling the results of SPK, PAK and PTA can produce potentially useful models for reporting program-specific pancreas transplant outcomes. This report describes the results of combining cohorts of simultaneous pancreas-kidney transplant, pancreas-afterkidney transplant, and pancreas transplant alone recipients to improve ascertainment of outcomes, and concludes that analyses based on the combined cohorts produce potentially useful models for reporting program-specific pancreas transplant outcomes. See editorial by Fridell and Stratta on page 251.

Original languageEnglish (US)
Pages (from-to)337-347
Number of pages11
JournalAmerican Journal of Transplantation
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Pancreas after kidney
  • Scientific Registry of Transplant Recipients
  • pancreas transplant alone
  • simultaneous pancreas-kidney transplant

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