Optimizing the immediate posttransplant prednisone dose - A prospective randomized trial

A. J. Matas, W. D. Payne, K. J. Gillingham, D. L. Dunn, D. E R Sutherland, J. S. Najarian

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Adult recipients of HLA non-identical living-related donor (LRD) kidneys were stratified into low-risk and high-risk groups and randomized to receive high-dose (starting at 1 mg/kg) vs. low-dose (starting at 30 mg/day) prednisone. Patient and graft survival and 1-year creatinine levels for the two groups were identical. The low-dose group had more rejections, only 38% of low-dose patients were rejection-free vs. 65% of high-dose patients (p < 0.05). In part, because of the increased incidence of rejection, the low-dose group had significantly more readmissions (p= 0.04). We conclude that, in LRD transplant recipients, low-dose and highdose prednisone protocols are associated with equivalent graft and patient survival. However, there is an increased incidence of rejection and readmissions with low-dose prednisone.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalClinical Transplantation
Volume6
Issue number2
StatePublished - 1992

Keywords

  • Immediate post-Tx
  • Prednisone

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