Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission

Vincent Gras, Benedikt A. Poser, Xiaoping Wu, Raphaël Tomi-Tricot, Nicolas Boulant

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The Human Connectome Project (HCP) has a 7T component that aims to study the human brain's organization and function with high spatial and temporal resolution fMRI and diffusion-weighted acquisitions. For whole brain applications at 7T, a major weakness however remains the heterogeneity of the radiofrequency transmission field (B 1 + ), which prevents from achieving an optimal signal and contrast homogeneously throughout the brain. In this work, we use parallel transmission (pTX) Universal Pulses (UP) to improve the flip angle homogeneity and demonstrate their application to highly accelerated multi-band EPI (MB5 and GRAPPA2, as prescribed in the 7T HCP protocol) sequence, but also to acquire at 7T B 1 + -artefact-free T 1 - and T 2 -weighted anatomical scans used in the pre-processing pipeline of the HCP protocol. As compared to typical implementations of pTX, the proposed solution is fully operator-independent and allows ”plug and play” exploitation of the benefits offered by multi-channel transmission. Validation in five healthy adults shows that the proposed technique achieves a flip angle homogeneity comparable to that of a clinical 3 T system. Compared to standard single-channel transmission, the use of UPs at 7T yielded up to a two-fold increase of the temporal signal-to-noise ratio in the temporal lobes as well as improved detection of functional connectivity in the brain regions most strongly affected by B 1 + inhomogeneity.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
StatePublished - Jul 15 2019


  • Calibration
  • Human connectome project
  • Multi-band EPI
  • Parallel transmission
  • RF shimming
  • Ultra-high field
  • Universal pulse

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission'. Together they form a unique fingerprint.

Cite this