Optimization of the reduction of                          74                         As(V) to                          74                         As(III) and of the labelling of dithiol dihydrolipoic acid

Zita Oláh; Andreas T.J. Vogg; Tibor Kremmer; Zoltán Szűcs; Zoltán Varga; Rita Dóczi

doi:10.1016/j.apradiso.2019.04.004

Optimization of the reduction of ⁷⁴ As(V) to ⁷⁴ As(III) and of the labelling of dithiol dihydrolipoic acid

Zita Oláh, Andreas T.J. Vogg, Tibor Kremmer, Zoltán Szűcs, Zoltán Varga, Rita Dóczi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	149
DOIs	https://doi.org/10.1016/j.apradiso.2019.04.004
State	Published - Jul 2019
Externally published	Yes

Bibliographical note

Funding Information:
This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013 ) and BMBF (Germany, grant 01DS14024 ).

Funding Information:
We thank to Prof. Dr. B. Neumaier and Dr. I. Spahn from the Research Centre Jülich, Institute for Neurosciences and Medicine, section Nuclear Chemistry (INM-5), for providing proton irradiated nat.GeO2 pellets containing 74As. This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013) and BMBF (Germany, grant 01DS14024).

Publisher Copyright:
© 2019

Publisher link

10.1016/j.apradiso.2019.04.004

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Cite this

Oláh, Z., Vogg, A. T. J., Kremmer, T., Szűcs, Z., Varga, Z., & Dóczi, R. (2019). Optimization of the reduction of ⁷⁴ As(V) to ⁷⁴ As(III) and of the labelling of dithiol dihydrolipoic acid. Applied Radiation and Isotopes, 149, 75-82. https://doi.org/10.1016/j.apradiso.2019.04.004

Optimization of the reduction of ⁷⁴ As(V) to ⁷⁴ As(III) and of the labelling of dithiol dihydrolipoic acid. / Oláh, Zita; Vogg, Andreas T.J.; Kremmer, Tibor et al.
In: Applied Radiation and Isotopes, Vol. 149, 07.2019, p. 75-82.

Research output: Contribution to journal › Article › peer-review

Oláh, Z, Vogg, ATJ, Kremmer, T, Szűcs, Z, Varga, Z & Dóczi, R 2019, 'Optimization of the reduction of ⁷⁴ As(V) to ⁷⁴ As(III) and of the labelling of dithiol dihydrolipoic acid', Applied Radiation and Isotopes, vol. 149, pp. 75-82. https://doi.org/10.1016/j.apradiso.2019.04.004

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abstract = "The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.",

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note = "Funding Information: This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013 ) and BMBF (Germany, grant 01DS14024 ). Funding Information: We thank to Prof. Dr. B. Neumaier and Dr. I. Spahn from the Research Centre J{\"u}lich, Institute for Neurosciences and Medicine, section Nuclear Chemistry (INM-5), for providing proton irradiated nat.GeO2 pellets containing 74As. This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013) and BMBF (Germany, grant 01DS14024). Publisher Copyright: {\textcopyright} 2019",

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