The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.
Bibliographical noteFunding Information:
This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013 ) and BMBF (Germany, grant 01DS14024 ).
PubMed: MeSH publication types
- Journal Article