Optimization of the explicit polarization (X-Pol) potential using a hybrid density functional

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The explicit polarization (X-Pol) method is a self-consistent fragment-based electronic structure theory in which molecular orbitals are block-localized within fragments of a cluster, macromolecule, or condensed-phase system. To account for short-range exchange repulsion and long-range dispersion interactions, we have incorporated a pairwise, empirical potential, in the form of Lennard-Jones terms, into the X-Pol effective Hamiltonian. In the present study, the X-Pol potential is constructed using the B3LYP hybrid density functional with the 6-31G(d) basis set to treat interacting fragments, and the Lennard-Jones parameters have been optimized on a dataset consisting of 105 bimolecular complexes. It is shown that the X-Pol potential can be optimized to provide a good description of hydrogen bonding interactions; the root mean square deviation of the computed binding energies from full (i. e., nonfragmental) CCSD(T)/aug-cc-pVDZ results is 0. 8 kcal/mol, and the calculated hydrogen bond distances have an average deviation of about 0. 1 Å from those obtained by full B3LYP/aug-cc-pVDZ optimizations.

Original languageEnglish (US)
Article number1161
Pages (from-to)1-15
Number of pages15
JournalTheoretical Chemistry Accounts
Issue number3
StatePublished - Mar 2012

Bibliographical note

Funding Information:
We thank Dr. Yen-lin Lin for assistance. This work has been supported by the National Institutes of Health (RC1-GM091445 and GM46736) and the National Science Foundation (CHE09-56776 and CHE09–57162).


  • Explicit polarization
  • Quantum force field
  • X-Pol


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