Optimization of compactin production by plackett-burman method using Penicillium citrinum

Mahin Basha Syed, Subhagar Seraman, Aravindan Rajendran, Viruthagiri Thangavelu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Plackett-Burman design was used to optimize various media compositions of carbon and nitrogen sources along with other nutrient parameters influencing the production of compactin under submerge fermentation. Initially eight different carbon sources were tested individually for compactin production. Among them glucose containing medium had produce maximum compactin. Secondly eight different nitrogen sources were tested, in which the medium containing urea and soybean meal had produce maximum compactin. The above carbon and nitrogen source was chosen for further optimization, eight nutrients such as (glucose, glycerol, soya bean meal, KH2PO4, urea, PEG, CaCl3.H2O and MgSO4.7H2O) were chosen for Plackett-Burman design with a 12 experimental runs. Among 8 factors studied by Plackett-Burman design, three factors had influenced the compactin production. The MgSO4.7H2O, KH2PO4 and glycerol medium constituents were found to be effective in the production of compactin by Penicillium citrinum. An improved compactin yield of 232.11 mg/L was obtained with optimized medium composition, which is higher production than previously obtained results.

Original languageEnglish (US)
Pages (from-to)1393-1400
Number of pages8
JournalInternational Journal of ChemTech Research
Issue number3
StatePublished - 2013


  • Compactin
  • Penicillium citrinum
  • Plackett-burman design and submerge fermentation


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