Optimal treatment and stochastic modeling of heterogeneous tumors

Hamidreza Badri, Kevin Leder

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In this work we review past articles that have mathematically studied cancer heterogeneity and the impact of this heterogeneity on the structure of optimal therapy. We look at past works on modeling how heterogeneous tumors respond to radiotherapy, and take a particularly close look at how the optimal radiotherapy schedule is modified by the presence of heterogeneity. In addition, we review past works on the study of optimal chemotherapy when dealing with heterogeneous tumors. Reviewers: This article was reviewed by Thomas McDonald, David Axelrod, and Leonid Hanin.

Original languageEnglish (US)
Article number40
JournalBiology Direct
Issue number1
StatePublished - Aug 23 2016

Bibliographical note

Funding Information:
Both HB and KL were supported by NSF grant CMMI-1362236.

Publisher Copyright:
© 2016 The Author(s).


  • Radiotherapy
  • Stochastic modeling
  • Tumor heterogeneity


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