Optimal P2Y12 Inhibitor in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Network Meta-Analysis

Asim M. Rafique, Piyush Nayyar, Tracy Y. Wang, Roxana Mehran, Usman Baber, Peter B. Berger, Jonathan Tobis, Jesse Currier, Ravi H. Dave, Timothy D. Henry

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Objectives The study sought to compare the clinical efficacy and safety of P2Y12 inhibitors in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous intervention (PPCI). Background Limited data exist regarding the comparative efficacy and safety of P2Y12 inhibitors in STEMI patients undergoing PPCI. Methods Clinical trials enrolling STEMI patients were identified and relevant data was extracted. Major adverse cardiovascular events (MACE) were defined as the composite of all cause mortality, MI, and target vessel revascularization. Network meta-analysis was performed using Bayesian methods. Results A total of 37 studies with 88,402 STEMI patients and 5,077 MACE were analyzed. Outcomes at 1 month (22 studies and 60,783 patients) suggest that prasugrel was associated with: lower MACE than clopidogrel (standard dose odds ratio [OR]: 0.59, 95% confidence interval [CI]: 0.50 to 0.69; high-dose OR: 0.60, 95% CI: 0.51 to 0.71; upstream OR: 0.79, 95% CI: 0.66 to 0.94), and ticagrelor (standard dose OR: 0.69, 95% CI: 0.56 to 0.84; upstream OR: 0.72, 95% CI: 0.50 to 1.05); lower mortality and MI than clopidogrel and standard ticagrelor; lower stroke risk than standard clopidogrel and standard or upstream ticagrelor; and lower stent thrombosis than standard or upstream clopidogrel. At 1-year (10 studies, n = 40,333) prasugrel was associated with lower mortality and MACE than other P2Y12 inhibitors. MACE was particularly lower with prasugrel in studies where patients received bivalirudin, drug-eluting stents, and but not glycoprotein IIb/IIIa inhibitor. Conclusions In STEMI patients undergoing PPCI, prasugrel and ticagrelor are more efficacious than clopidogrel; in addition, prasugrel was superior to ticagrelor particularly in conjunction with bivalirudin and drug-eluting stents.

Original languageEnglish (US)
Pages (from-to)1036-1046
Number of pages11
JournalJACC: Cardiovascular Interventions
Issue number10
StatePublished - May 23 2016

Bibliographical note

Publisher Copyright:
© 2016 American College of Cardiology Foundation.


  • P2Y inhibitors
  • ST-segment elevation myocardial infarction
  • angioplasty
  • clopidogrel
  • percutaneous coronary intervention
  • prasugrel
  • thienopyridines
  • ticagrelor


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