Optimal design of offset-specific radio frequency pulses for solution and solid-state NMR using a genetic algorithm

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we describe the necessary steps to optimize the design of radiofrequency pulses for solution and solid-state NMR spectroscopy using a genetic algorithm (GA). We show that GA-optimized pulses significantly improve both sensitivity and resolution of NMR experiments, eliminating experimental imperfections. Additionally, we demonstrate the use of GA optimization to design band-selective pulses and manipulate individual spin systems with significantly different chemical shifts such as carbonyl and aliphatic carbon nuclei. These new offset-specific pulses (OSP) are of general use and can perform various operations on nuclei based on their chemical shift offsets. Replacing multiple band selective pulses with a single OSP can dramatically reduce pulsing time and power in classical NMR pulse sequences, increasing the sensitivity in multidimensional experiments.

Original languageEnglish (US)
Title of host publicationModern Magnetic Resonance
PublisherSpringer International Publishing
Pages605-615
Number of pages11
ISBN (Electronic)9783319283883
ISBN (Print)9783319283876
DOIs
StatePublished - Jun 13 2018

Keywords

  • Broad-band pulses
  • Composite pulses
  • Genetic algorithm optimization
  • NMR pulse design
  • RF inhomogeneity

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