Optically Detected Magnetic Resonance for Selective Imaging of Diamond Nanoparticles

Margaret E. Robinson, James D. Ng, Huilong Zhang, Joseph T. Buchman, Olga A. Shenderova, Christy L. Haynes, Zhenqiang Ma, Randall H. Goldsmith, Robert J. Hamers

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

While there is great interest in understanding the fate and transport of nanomaterials in the environment and in biological systems, the detection of nanomaterials in complex matrices by fluorescence methods is complicated by photodegradation, blinking, and the presence of natural organic material and other fluorescent background signals that hamper detection of fluorescent nanomaterials of interest. Optically detected magnetic resonance (ODMR) of nitrogen-vacancy (NV) centers in diamond nanoparticles provides a pathway toward background-free fluorescence measurements, as the application of a resonant microwave field can selectively modulate the intensity from NV centers in nanodiamonds of various diameters in complex materials systems using on-resonance and off-resonance microwave fields. This work represents the first investigation showing how nanoparticle diameter impacts the NV center lifetime and thereby directly impacts the accessible contrast and signal-to-noise ratio when using ODMR to achieve background-free imaging of NV-nanodiamonds in the presence of interfering fluorophores. These results provide new insights that will guide the choice of optimum nanoparticle size and methodology for background-free imaging and sensing applications, while also providing a model system to explore the fate and transport of nanomaterials in the environment.

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalAnalytical Chemistry
Volume90
Issue number1
DOIs
StatePublished - Jan 2 2018

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation (NSF) via the Centers for Chemical Innovation Program Award CHE-1503408, the Center for Sustainable Nanotechnology. J.T.B. was supported by the University of Minnesota Biotechnology Training Grant Program through the National Institutes of Health. Fabrication of microwave antennas was supported by Office of Naval Research Grant No. N00014-13-1-0226 to Z.M. TEM work in this study was carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program. R.H.G. and J.N. acknowledge support from the National Science Foundation via Grant No. CHE-1254936 for initial studies of NV resonance phenomena. NV nanodiamond samples were produced by Adaḿ as Nanotechnologies using support from the National Heart, Lung, and Blood Institute, National Institutes of Health (NIHLBI), under Contract No. HHSN268201500010. We acknowledge F. J. Heremans and D. D. Awschalom for helpful conversations, C. N. Nunn of Adaḿ as for help with sample preparation, and A. Shames of Ben-Gurion University of Negev for providing EPR data on NV center content in the samples.

Funding Information:
This work was supported by the National Science Foundation (NSF) via the Centers for Chemical Innovation Program Award CHE-1503408 the Center for Sustainable Nanotechnology. J.T.B. was supported by the University of Minnesota Biotechnology Training Grant Program through the National Institutes of Health. Fabrication of microwave antennas was supported by Office of Naval Research Grant No. N00014-13-1-0226 to Z.M. TEM work in this study was carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program. R.H.G. and J.N. acknowledge support from the National Science Foundation via Grant No. CHE-1254936 for initial studies of NV resonance phenomena. NV nanodiamond samples were produced by Adamas Nanotechnologies using support from the National Heart, Lung, and Blood Institute National Institutes of Health (NIHLBI), under Contract No. HHSN268201500010. We acknowledge F. J. Heremans and D. D. Awschalom for helpful conversations C. N. Nunn of Adamas for help with sample preparation, and A. Shames of Ben-Gurion University of Negev for providing EPR data on NV center content in the samples.

How much support was provided by MRSEC?

  • Shared

Reporting period for MRSEC

  • Period 4

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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