Optical Control of Microtubule Dynamics in Time and Space

Brian T. Castle, David J. Odde

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations

Abstract

Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

Original languageEnglish (US)
Article number8312
Pages (from-to)243-245
Number of pages3
JournalCell
Volume162
Issue number2
DOIs
StatePublished - Jul 18 2015

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