Optical Control of Microtubule Dynamics in Time and Space

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations

Abstract

Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

Original languageEnglish (US)
Article number8312
Pages (from-to)243-245
Number of pages3
JournalCell
Volume162
Issue number2
DOIs
StatePublished - Jul 18 2015

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