Optical Control of Microtubule Dynamics in Time and Space

Brian T. Castle; David J. Odde

doi:10.1016/j.cell.2015.06.064

Optical Control of Microtubule Dynamics in Time and Space

Brian T. Castle, David J. Odde

Biomedical Engineering

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

Original language	English (US)
Article number	8312
Pages (from-to)	243-245
Number of pages	3
Journal	Cell
Volume	162
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2015.06.064
State	Published - Jul 18 2015

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10.1016/j.cell.2015.06.064

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Optical Control of Microtubule Dynamics in Time and Space

Abstract

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