Opposing consequences of signaling through egf family members: Escape from ctls could be a bait for nk cells

Rolf Kiessling, Riki Okita, Dimitrios Mougiakakos, Yumeng Mao, Dhifaf Sarhan, Erik Wennerberg, Barbara Seliger, Andreas Lundqvist, Kousaku Mimura, Koji Kono

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Oncogenes have been traditionally viewed as molecular drivers for tumor growth and survival. Recent evidence indicates that oncogenes may facilitate the escape of malignant cells from immune recognition and elimination. In this article, we discuss the implications of the overexpression of epidermal growth factor receptor (EGFR) family members on immune escape of tumors and immunotherapy.

Original languageEnglish (US)
Pages (from-to)1200-1201
Number of pages2
JournalOncoImmunology
Volume1
Issue number7
DOIs
StatePublished - Dec 1 2012

Keywords

  • EGF receptors
  • Immune escape
  • MHC Class I
  • MICA/B
  • NK cell

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