Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF

Huda Zahid; Noelle M. Olson; William C.K. Pomerantz

doi:10.1016/j.cbpa.2021.02.003

Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF

Huda Zahid, Noelle M. Olson, William C.K. Pomerantz

Chemistry (Twin Cities)

Research output: Contribution to journal › Review article › peer-review

Abstract

Nucleosome remodeling provides access to genomic DNA for recruitment of the transcriptional machinery to mediate gene expression. The aberrant function of nucleosome remodeling complexes has been correlated to human cancer, making them emerging therapeutic targets. The bromodomain PHD finger transcription factor, BPTF, is the largest member of the human nucleosome remodeling factor NURF. Over the last five years, BPTF has become increasingly identified as a protumorigenic factor, prompting investigations into the molecular mechanisms associated with BPTF function. Despite a druggable bromodomain, small molecule discovery is at an early stage. Here we highlight recent investigations into the biology being discovered for BPTF, chemical biology approaches used to study its function, and small molecule inhibitors being designed as future chemical probes and therapeutics.

Original language	English (US)
Pages (from-to)	57-67
Number of pages	11
Journal	Current opinion in chemical biology
Volume	63
Early online date	Mar 8 2021
DOIs	https://doi.org/10.1016/j.cbpa.2021.02.003
State	Published - Aug 2021

Bibliographical note

Funding Information:
This work was supported by the National Institute of General Medical Sciences [R01GM121414-04], the National Institutes of Health Biotechnology Training Grant [5T32GM008347-23, N.M.O], and the University of Minnesota IEM Engineering in Medicine Doctoral Fellowship 2020 (H.Z) for financial support. We would also like to acknowledge BioRender, which was used to create all figures in this report.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

BPTF
Bromodomain
Chemical epigenetics
Chemical probe
NURF

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.cbpa.2021.02.003

Cite this

@article{5fba418f45734b2d9ebe6bcc6013daf5,

title = "Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF",

abstract = "Nucleosome remodeling provides access to genomic DNA for recruitment of the transcriptional machinery to mediate gene expression. The aberrant function of nucleosome remodeling complexes has been correlated to human cancer, making them emerging therapeutic targets. The bromodomain PHD finger transcription factor, BPTF, is the largest member of the human nucleosome remodeling factor NURF. Over the last five years, BPTF has become increasingly identified as a protumorigenic factor, prompting investigations into the molecular mechanisms associated with BPTF function. Despite a druggable bromodomain, small molecule discovery is at an early stage. Here we highlight recent investigations into the biology being discovered for BPTF, chemical biology approaches used to study its function, and small molecule inhibitors being designed as future chemical probes and therapeutics.",

keywords = "BPTF, Bromodomain, Chemical epigenetics, Chemical probe, NURF",

author = "Huda Zahid and Olson, {Noelle M.} and Pomerantz, {William C.K.}",

note = "Funding Information: This work was supported by the National Institute of General Medical Sciences [R01GM121414-04], the National Institutes of Health Biotechnology Training Grant [5T32GM008347-23, N.M.O], and the University of Minnesota IEM Engineering in Medicine Doctoral Fellowship 2020 (H.Z) for financial support. We would also like to acknowledge BioRender, which was used to create all figures in this report. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = aug,

doi = "10.1016/j.cbpa.2021.02.003",

language = "English (US)",

volume = "63",

pages = "57--67",

journal = "Current Opinion in Chemical Biology",

issn = "1367-5931",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF

AU - Zahid, Huda

AU - Olson, Noelle M.

AU - Pomerantz, William C.K.

N1 - Funding Information: This work was supported by the National Institute of General Medical Sciences [R01GM121414-04], the National Institutes of Health Biotechnology Training Grant [5T32GM008347-23, N.M.O], and the University of Minnesota IEM Engineering in Medicine Doctoral Fellowship 2020 (H.Z) for financial support. We would also like to acknowledge BioRender, which was used to create all figures in this report. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/8

Y1 - 2021/8

N2 - Nucleosome remodeling provides access to genomic DNA for recruitment of the transcriptional machinery to mediate gene expression. The aberrant function of nucleosome remodeling complexes has been correlated to human cancer, making them emerging therapeutic targets. The bromodomain PHD finger transcription factor, BPTF, is the largest member of the human nucleosome remodeling factor NURF. Over the last five years, BPTF has become increasingly identified as a protumorigenic factor, prompting investigations into the molecular mechanisms associated with BPTF function. Despite a druggable bromodomain, small molecule discovery is at an early stage. Here we highlight recent investigations into the biology being discovered for BPTF, chemical biology approaches used to study its function, and small molecule inhibitors being designed as future chemical probes and therapeutics.

AB - Nucleosome remodeling provides access to genomic DNA for recruitment of the transcriptional machinery to mediate gene expression. The aberrant function of nucleosome remodeling complexes has been correlated to human cancer, making them emerging therapeutic targets. The bromodomain PHD finger transcription factor, BPTF, is the largest member of the human nucleosome remodeling factor NURF. Over the last five years, BPTF has become increasingly identified as a protumorigenic factor, prompting investigations into the molecular mechanisms associated with BPTF function. Despite a druggable bromodomain, small molecule discovery is at an early stage. Here we highlight recent investigations into the biology being discovered for BPTF, chemical biology approaches used to study its function, and small molecule inhibitors being designed as future chemical probes and therapeutics.

KW - BPTF

KW - Bromodomain

KW - Chemical epigenetics

KW - Chemical probe

KW - NURF

UR - http://www.scopus.com/inward/record.url?scp=85102027653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85102027653&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2021.02.003

DO - 10.1016/j.cbpa.2021.02.003

M3 - Review article

C2 - 33706239

AN - SCOPUS:85102027653

VL - 63

SP - 57

EP - 67

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

ER -

Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Access

Other files and links

Fingerprint

Cite this