Opioids in the nucleus of the solitary tract are involved in feeding in the rat

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Abstract

We evaluated the effect of selective opioid peptides and naltrexone on feeding when injected into the nucleus of the solitary tract (NTS). Doses of 0, 1, 2, 4, and 8 nmol of [D-Ala 2,N-Me-Phe 4,Gly 5-ol]enkephalin (DAMGO, μ-agonist), dynorphin A-(1-17) (DynA-(l-17), κ-agonist), and [D-Ser 2]leucine enkephalin-thr, (S-agonist) were injected into the NTS in satiated male rats, and food intake was measured at 1, 2, and 4 h. Only DAMGO significantly increased feeding above control levels at doses of 2, 4, and 8 nmol. Doses of 10 and 50 μg naltrexone in the NTS significantly decreased 18-h deprivation-induced feeding. These data suggest that NTS opioid receptors (primarily μ) may be involved in the regulation of feeding. [D-Ala 2, N-Mc-Phe 4,Gly 5-ol]enkephalin; [D-Ser 2]leucine enkephalin-thr; dynorphin A-(1-17); naltrexone

Original languageEnglish (US)
JournalAmerican Journal of Physiology
Volume272
Issue number4 PART 2
StatePublished - 1997

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