TY - JOUR
T1 - Opioids in the nucleus of the solitary tract are involved in feeding in the rat
AU - Kotz, C. M.
AU - Billington, C. J.
AU - Levine, A. S.
PY - 1997
Y1 - 1997
N2 - We evaluated the effect of selective opioid peptides and naltrexone on feeding when injected into the nucleus of the solitary tract (NTS). Doses of 0, 1, 2, 4, and 8 nmol of [D-Ala 2,N-Me-Phe 4,Gly 5-ol]enkephalin (DAMGO, μ-agonist), dynorphin A-(1-17) (DynA-(l-17), κ-agonist), and [D-Ser 2]leucine enkephalin-thr, (S-agonist) were injected into the NTS in satiated male rats, and food intake was measured at 1, 2, and 4 h. Only DAMGO significantly increased feeding above control levels at doses of 2, 4, and 8 nmol. Doses of 10 and 50 μg naltrexone in the NTS significantly decreased 18-h deprivation-induced feeding. These data suggest that NTS opioid receptors (primarily μ) may be involved in the regulation of feeding. [D-Ala 2, N-Mc-Phe 4,Gly 5-ol]enkephalin; [D-Ser 2]leucine enkephalin-thr; dynorphin A-(1-17); naltrexone
AB - We evaluated the effect of selective opioid peptides and naltrexone on feeding when injected into the nucleus of the solitary tract (NTS). Doses of 0, 1, 2, 4, and 8 nmol of [D-Ala 2,N-Me-Phe 4,Gly 5-ol]enkephalin (DAMGO, μ-agonist), dynorphin A-(1-17) (DynA-(l-17), κ-agonist), and [D-Ser 2]leucine enkephalin-thr, (S-agonist) were injected into the NTS in satiated male rats, and food intake was measured at 1, 2, and 4 h. Only DAMGO significantly increased feeding above control levels at doses of 2, 4, and 8 nmol. Doses of 10 and 50 μg naltrexone in the NTS significantly decreased 18-h deprivation-induced feeding. These data suggest that NTS opioid receptors (primarily μ) may be involved in the regulation of feeding. [D-Ala 2, N-Mc-Phe 4,Gly 5-ol]enkephalin; [D-Ser 2]leucine enkephalin-thr; dynorphin A-(1-17); naltrexone
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U2 - 10.1152/ajpregu.1997.272.4.r1028
DO - 10.1152/ajpregu.1997.272.4.r1028
M3 - Article
C2 - 9139997
AN - SCOPUS:0030908623
SN - 0002-9513
VL - 272
SP - R1028-R1032
JO - American Journal of Physiology
JF - American Journal of Physiology
IS - 4 PART 2
ER -