Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library

David A. Lippman, Nancy M. Lee, Horace H Loh

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22 Scopus citations


A rat brain cDNA library was screened with probes constructed from portions of the cDNA (OBCAM) encoding the opioid-binding cell adhesion molecule (OBCAM). Three clones of interest were isolated and sequenced. The largest clone, DUZ1, had a putative open reading frame (ORF) essentially identical to OBCAM in its C-terminal 318 amino acids (aa), but differing in its N-terminal aa (20 vs. 27 in OBCAM), and in all of its 5′-noncoding regions. The other clones, SG8 and SG13, had a putative ORF essentially identical to that of OBCAM, but differed from each other in a portion of their 5′-noncoding region. This study suggests that there is a family of OBCAM-like genes.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
Issue number2
StatePublished - Aug 15 1992

Bibliographical note

Funding Information:
This work was supported in part by NIDA research grants 00564 (H.H.L.), 05695 (H.H.L.), 01583 (H.H.L.), 02643 (N.M.L.), and Research Scientist Award K05-DA70554 (H.H.L.) and K05-DA00020 (N.M.L.) and the F. Stark endowed Fund in Minnesota Medical Foundation. D.A.L. is currently registered in the graduate program in the Department of Pharmacology, University of California, San Francisco.


  • Opioid receptor
  • cDNA cloning
  • cell adhesion molecules
  • immunoglobulin superfamily


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