Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library

David A. Lippman, Nancy M. Lee, Horace H Loh

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A rat brain cDNA library was screened with probes constructed from portions of the cDNA (OBCAM) encoding the opioid-binding cell adhesion molecule (OBCAM). Three clones of interest were isolated and sequenced. The largest clone, DUZ1, had a putative open reading frame (ORF) essentially identical to OBCAM in its C-terminal 318 amino acids (aa), but differing in its N-terminal aa (20 vs. 27 in OBCAM), and in all of its 5′-noncoding regions. The other clones, SG8 and SG13, had a putative ORF essentially identical to that of OBCAM, but differed from each other in a portion of their 5′-noncoding region. This study suggests that there is a family of OBCAM-like genes.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalGene
Volume117
Issue number2
DOIs
StatePublished - Aug 15 1992

Keywords

  • Opioid receptor
  • cDNA cloning
  • cell adhesion molecules
  • immunoglobulin superfamily

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