TY - JOUR
T1 - Opioid antagonist effects on self-injury in adults with mental retardation
T2 - Response form and location as determinants of medication effects
AU - Thompson, T.
AU - Hackenberg, T.
AU - Cerutti, D.
AU - Baker, D.
AU - Axtell, S.
PY - 1994
Y1 - 1994
N2 - The opioid antagonist naltrexone was administered to 8 adults with severe or profound mental retardation and extensive histories of self-injurious behavior. Five-minute behavioral samples were observed randomly out of every hour from 8 a.m. through 3 p.m., Monday through Friday, for four 2-week phases (baseline, placebo, 50 mg, and 100 mg). During naltrexone administration, there were fewer days with frequent head-banging and self- biting, whereas there were more days on which blows to the head or self- biting were infrequent. Self-injurious participants slept 1.38 hours less per night during baseline, which was unaffected by naltrexone.
AB - The opioid antagonist naltrexone was administered to 8 adults with severe or profound mental retardation and extensive histories of self-injurious behavior. Five-minute behavioral samples were observed randomly out of every hour from 8 a.m. through 3 p.m., Monday through Friday, for four 2-week phases (baseline, placebo, 50 mg, and 100 mg). During naltrexone administration, there were fewer days with frequent head-banging and self- biting, whereas there were more days on which blows to the head or self- biting were infrequent. Self-injurious participants slept 1.38 hours less per night during baseline, which was unaffected by naltrexone.
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M3 - Article
C2 - 7946257
AN - SCOPUS:0028290474
VL - 99
SP - 85
EP - 102
JO - American Journal on Mental Retardation
JF - American Journal on Mental Retardation
SN - 1944-7515
IS - 1
ER -