Opiate binding to cerebroside sulfate: A model system for opiate-receptor interaction

Horace H. Loh; T. M. Cho; Y. C. Wu; R. A. Harris; E. L. Way

doi:10.1016/0024-3205(75)90281-7

Opiate binding to cerebroside sulfate: A model system for opiate-receptor interaction

Horace H. Loh, T. M. Cho, Y. C. Wu, R. A. Harris, E. L. Way

Pharmacology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cerebroside sulfate was shown to bind etorphine and levorphanol with high affinity. The relative potency of narcotic analgesics in preventing the binding of levorphanol to cerebroside sulfate correlated well with their reported analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Some preliminary animal data also imply the involvement of CS in opiate action We, therefore, propose that CS may serve as a useful "receptor" model for the study of opiate-receptor interaction in vitro.

Original language	English (US)
Pages (from-to)	1811-1817
Number of pages	7
Journal	Life Sciences
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(75)90281-7
State	Published - Jun 15 1975

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T1 - Opiate binding to cerebroside sulfate

T2 - A model system for opiate-receptor interaction

AU - Loh, Horace H.

AU - Cho, T. M.

AU - Wu, Y. C.

AU - Harris, R. A.

AU - Way, E. L.

PY - 1975/6/15

Y1 - 1975/6/15

N2 - Cerebroside sulfate was shown to bind etorphine and levorphanol with high affinity. The relative potency of narcotic analgesics in preventing the binding of levorphanol to cerebroside sulfate correlated well with their reported analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Some preliminary animal data also imply the involvement of CS in opiate action We, therefore, propose that CS may serve as a useful "receptor" model for the study of opiate-receptor interaction in vitro.

AB - Cerebroside sulfate was shown to bind etorphine and levorphanol with high affinity. The relative potency of narcotic analgesics in preventing the binding of levorphanol to cerebroside sulfate correlated well with their reported analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Some preliminary animal data also imply the involvement of CS in opiate action We, therefore, propose that CS may serve as a useful "receptor" model for the study of opiate-receptor interaction in vitro.

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ER -

Opiate binding to cerebroside sulfate: A model system for opiate-receptor interaction

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