Opiate antagonists: central sites of action in suppressing water intake of the rat

David R. Brown, Stephen G. Holtzman

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The pure opiate antagonists, naloxone and naltrexone (0.1-10 mg/kg), dose-dependently suppressed water intake of 24 h water-deprived rats upon subcutaneous administration; their quaternary derivatives, methyl-naloxone and methyl-naltrexone, which are impermeable to the blood-brain barrier, failed to affect drinking. Upon intracerebroventricular administration, both quaternary analogs attenuated drinking at a dose of only 10 μg. These results demonstrate that the antidipsogenic effects of opiate antagonists are primarily mediated at sites within the central nervous system.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalBrain Research
Volume221
Issue number2
DOIs
StatePublished - Sep 28 1981

Keywords

  • central
  • drinking
  • naloxone
  • naltrexone
  • quaternary narcotic antagonists
  • site of action

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